I often combine the two, Kenalog and 5-FU, as an injectble combination when either it is a known problematic scar or a scar that has failed to respond to Kenalog injections. Side effects. Im afraid that the doc wont tell me the truth wanting me to pay him … Occasionally the pain was severe and persisted for 2 hours after injection.

Generally intralesional kenalog/cortisone injection is the treatment of choice, and is often done every 4-6 weeks for 4-8 treatments, but may even need to be repeated in the future as keloids occasionally recur. 5-FU is not a ‘magic bullet’ but it does offer another option for difficult scar problems. Mild side-effects, due to local toxicity advise against using higher concentrations. Besides excision and intralesional 5-FU, a maximum of one other treatment modality has been used when indicated (triamcinolone acetonide (TAC), botulinum toxin, silicone sheets).a Level of evidence rated by Centre for Evidence Based Medicine criteria, March 2009 (www.cebm.net). Although having a … Effects of 5-FU Adv Exp Med Biol.

Fitzpatrick (1999) was the first to use TAC/5-FU combination in the treatment of keloids and hypertrophic scars.
The intra-lesional injection of 5-fluorouracil (5-FU) is a promising therapy to treat keloid. But given the relatively poor response to treatment of most keloids with steroids, I will consider 5-FU injections for future cases. To evaluate the efficacy and side effects of 5-fluorouracil (5-FU) as a therapeutic agent in the treatment of keloids of any duration or size.

The intra-lesional injection of 5-fluorouracil (5-FU) is a promising therapy to treat keloid. All 20 patients found the injections painful. hello be very careful with the steroid injections on your keloid. In a similar study, Nanda and Reddy studied the effects of 5-FU in 28 patients with keloids on the chest, shoulder, upper arms, back, and additional locations. He reported a 9-year experience administering more than 5000 injections of 5-FU to more than 1000 patients. Hidden side effects ? Lower concentrations would require more volume for the same active dose, which increases pain on injection. Are there any negative side effects of 5-FU injections on keloid treatment? He found that by mixing 1 mg/ml TAC with 5-FU, the efficacy was improved and injections were less painful. For hypertrophic scars, I am not so sure but the apparent lack of any side effects (steroids are well known to cause tissue thinning and atrophy) gives it some appeal. Thank you There are a number of treatment options available to remove or improve the appearance of keloid scars.
I found a doctor that uses the combo 5 fu plus kenalog to treat keloids but i was wondering why there are so few doctors that use this treatmet ,it cause is not safe ? There are a number of clinical studies on the efficacy of 5-FU in keloid treatment that revealed promising results. I had exactly the same problem egg shaped lipoma in my colon causing bowel obstruction. When deciding which treatment option (or combination of) is best for a patient, doctors will look at the following factors: 3 also investigated the effects of intralesional 5-FU in 20 patients with keloid lesions on various locations including the chest, back, extremities, and earlobes. After some googling, I found that it is a chemo medication. Without exception the manufacturer concentration of 50 mg/ml was used when 5-FU was used alone. Adding 5-FU to kenalog can be beneficial in some cases, as can doing liquid nitrogen prior to the injection (especially in lighter skin types). Overview of Keloid Treatment Options. A total of 4 patients found the pain intolerable so we had to combine intralesional 5-FU with 2% xylocaine. In addition, the side effects of steroid injections are common and significant. It does not have the side effects of corticosteriods but injections are still done only every month or so, mainly to see how it is working. Eight patients had previously failed to respond to triamcinolone acetonide (TAC) 40 mg/cc injections every 3 weeks. b No 0%, poor 1–25%, fair 26–50%, good 51–75%, excellent 76–100% keloid flattening.

Don't overdue the injections or it can cause denting in your skin. The intra-lesional injection of 5-fluorouracil (5-FU) is a promising therapy to treat keloid. Working as an antimetabolite to prevent cell proliferation, it primarily inhibits the enzyme thymidylate synthase blocking the thymidine formation required for DNA synthesis. 5-fluorouracil (5-FU) is a chemotherapeutical agent used to treat cancers including breast and colorectal. The vertical scar is 6 + inches.

Kontochristopoulus et al. I was talking to a friend about treatment for keloid scars and he said he had some luck with 5-FU injections and I should bring it up with my dermatologist. Eleven patients had previously failed treatment with steroid injections, silicone gels, surgical excision, and cryotherapy.
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